GLP-1 moiety from Dulaglutide (CAS 923950-08-7) – Wholesale & Research Grade
Dulaglutide, a GLP-1 (glucagon-like peptide-1) receptor agonist, has emerged as a significant therapeutic agent in the management of type 2 diabetes mellitus. Its research applications extend to weight management and cardiovascular risk reduction, making it a multifaceted tool in metabolic disease intervention.
Mechanism of Action
The mechanism of action for Dulaglutide involves the enhancement of glucose-dependent insulin secretion, which is pivotal in regulating blood glucose levels. By mimicking the natural hormone GLP-1, Dulaglutide also suppresses glucagon secretion, slows gastric emptying, and promotes satiety—thereby helping to control appetite and improve glycemic control. This multifactorial approach not only aids in blood sugar regulation but also contributes to weight loss, providing a dual benefit for patients managing obesity alongside diabetes.
Solubility and Storage Advice
Dulaglutide is typically soluble in aqueous solutions, which makes it suitable for subcutaneous administration. For optimal stability and efficacy, it should be stored in a refrigerator at temperatures between 2°C and 8°C. It is crucial to avoid freezing the solution, as this may compromise its integrity. Once in use, the product can remain at room temperature for a limited duration, following specific guidelines to maintain its therapeutic effectiveness.
Future Research Directions
Future research on Dulaglutide is poised to explore its potential beyond diabetes management. Studies are underway to investigate its effectiveness in treating other metabolic disorders and its impact on cardiovascular health. Additionally, researchers are examining the long-term effects of GLP-1 receptor agonists in various patient populations, including those with chronic kidney disease. Novel formulations and delivery systems are also being developed to enhance patient adherence and improve therapeutic outcomes.
In summary, Dulaglutide represents a promising GLP-1 moiety with multifaceted applications, and ongoing research continues to uncover its potential benefits in broader health contexts.
| CAS Number | 923950-08-7 |
|---|---|
| Formula | C149H221N37O49 |
| Mol. Weight | 3314.6 g/mol |
| IUPAC Name | (4S)-5-[[2-[[(2S,3R)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)... |
| Grade | HPLC ≥98% |
Synthesis & Storage
GLP-1 moiety from Dulaglutide is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 923950-08-7, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.