Tesofensine (CAS 195875-84-4) – Wholesale & Research Grade
Tesofensine, a potent serotonin-norepinephrine-dopamine reuptake inhibitor, has garnered significant attention in the field of obesity and metabolic research. Originally developed as a treatment for neurodegenerative diseases, its unique mechanism of action has led to its repurposing for weight management applications. Tesofensine works by increasing the levels of neurotransmitters in the brain, which helps to suppress appetite and enhance energy expenditure, providing a dual approach to weight loss.
Research Applications
Recent studies have indicated that Tesofensine may be effective not only in reducing body weight but also in improving metabolic parameters associated with obesity. Research has explored its potential in treating conditions such as type 2 diabetes and metabolic syndrome, making it a compound of interest for various therapeutic avenues. Additionally, ongoing clinical trials are investigating its efficacy and safety in diverse populations, including those with comorbid conditions.
Mechanism of Action
The mechanism of Tesofensine revolves around its ability to inhibit the reuptake of key neurotransmitters—serotonin, norepinephrine, and dopamine. By enhancing the availability of these neurotransmitters in the synaptic cleft, Tesofensine promotes satiety and regulates energy balance, thereby aiding weight loss. This action not only addresses obesity but also has implications for improving mood and cognitive function, making it an exciting candidate for further exploration.
Solubility and Storage Advice
Tesofensine exhibits solubility in organic solvents, making it suitable for various formulations. For optimal stability, it should be stored in a cool, dry place, away from light and moisture. Proper handling protocols should be observed to maintain its integrity during research and application.
Future Research Directions
- Exploring the long-term effects of Tesofensine on weight maintenance.
- Investigating its role in improving mental health outcomes in obese individuals.
- Developing formulations for enhanced delivery and patient compliance.
As research continues, Tesofensine presents a promising avenue for developing innovative approaches to obesity and related metabolic disorders.
| CAS Number | 195875-84-4 |
|---|---|
| Formula | C17H23Cl2NO |
| Mol. Weight | 328.3 g/mol |
| IUPAC Name | (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3... |
| Grade | HPLC ≥98% |
Synthesis & Storage
Tesofensine is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 195875-84-4, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.