NNMTi (CAS 42464-96-0) – Wholesale & Research Grade
NNMTi, a notable inhibitor of nicotinamide N-methyltransferase (NNMT), has garnered significant interest in the field of metabolic research and potential therapeutic applications. As a research tool, NNMTi aids in exploring the role of NNMT in various physiological and pathological processes, particularly in metabolic disorders, cancer, and neurodegenerative diseases. Its capacity to modulate methylation pathways makes it valuable for studying the intricate balance of methylation and its implications in health and disease.
Mechanism of Action
NNMTi functions by selectively inhibiting the activity of NNMT, an enzyme involved in the transfer of methyl groups from S-adenosylmethionine (SAM) to nicotinamide. This inhibition leads to an accumulation of nicotinamide and alterations in the levels of other metabolites involved in critical biochemical pathways. By disrupting the normal methylation processes, NNMTi can impact various signaling pathways and metabolic functions, making it a crucial compound for dissecting the role of methylation in cellular processes.
Solubility and Storage Advice
- NNMTi is soluble in organic solvents such as DMSO and ethanol, allowing for flexible application in laboratory settings.
- For optimal stability, it is recommended to store NNMTi in a cool, dry place, away from light, and under inert gas conditions when necessary.
- Reconstituted solutions should be used promptly or stored at low temperatures to maintain compound integrity.
Future Research Directions
The ongoing exploration of NNMTi's therapeutic potential is promising, particularly in the context of metabolic syndrome and cancer therapy. Future studies may focus on its efficacy in animal models, elucidating the pathways influenced by NNMT inhibition. Additionally, researchers are encouraged to investigate NNMTi's role in combination therapies, especially in conjunction with other metabolic modulators. Understanding the broader implications of NNMT inhibition could lead to novel treatment strategies for diseases associated with dysregulated methylation.
| CAS Number | 42464-96-0 |
|---|---|
| Formula | C10H11IN2 |
| Mol. Weight | 286.11 g/mol |
| IUPAC Name | 1-methylquinolin-1-ium-5-amine iodide |
| Grade | HPLC ≥98% |
Synthesis & Storage
NNMTi is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 42464-96-0, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.