Bremelanotide (CAS 189691-06-3) – Research Grade is a high-purity chemical compound.

Bremelanotide is an oligopeptide.

Research Context

Bremelanotide, commonly known as PT-141 or Bremelanotide Acetate, is a synthetic peptide that has garnered significant interest in the fields of sexual medicine and neurobiology. Originally developed for its potential in treating male erectile dysfunction, recent research has expanded its applications to include female sexual arousal disorder and other sexual dysfunctions.

Research Applications

This compound acts primarily on the melanocortin receptors, specifically the MC3R and MC4R, which play crucial roles in sexual arousal and appetite regulation. Studies have demonstrated that Bremelanotide can enhance sexual desire and arousal in both men and women, making it a valuable candidate in the exploration of treatments for sexual dysfunctions. Additionally, its potential effects on mood and anxiety have prompted investigations into its applications for broader neuropsychological conditions.

Mechanism of Action

Bremelanotide functions as a melanocortin receptor agonist. By binding to these receptors in the central nervous system, it stimulates pathways that regulate sexual behavior and arousal. Unlike traditional erectile dysfunction medications that focus on vascular mechanisms, Bremelanotide's unique mechanism allows it to enhance libido and sexual satisfaction, providing a different therapeutic approach.

Solubility and Storage Advice

Bremelanotide is typically soluble in water, which facilitates its administration routes, often via subcutaneous injection. It is essential to store this peptide in a cool, dry place, ideally at temperatures between 2-8°C when in powder form. Once reconstituted, it should be refrigerated and used within a specified timeframe to maintain its effectiveness and stability.

Future Research Directions

Future studies on Bremelanotide may focus on optimizing dosing regimens, understanding long-term effects, and exploring its potential in treating other forms of sexual dysfunction. Additionally, ongoing research aims to investigate its role in modulating emotional responses and its implications in treating mood disorders. The promise of Bremelanotide as a multi-faceted therapeutic agent underscores the importance of continued exploration in both clinical and preclinical settings.