Setmelanotide (CAS 920014-72-8) – Wholesale & Research Grade
Setmelanotide, a synthetic peptide, has garnered significant attention in the field of obesity and metabolic disorders. It primarily acts as a melanocortin-4 receptor (MC4R) agonist, which plays a crucial role in the regulation of appetite and energy homeostasis. Due to its specific mechanism of action, setmelanotide is being explored for the treatment of genetic obesity syndromes, particularly those associated with defects in the melanocortin pathway.
Research Applications
Setmelanotide is currently being investigated for its efficacy in treating patients with rare genetic conditions such as Bardet-Biedl syndrome and POMC deficiency. Clinical studies have shown promising results in weight reduction and improved metabolic parameters among subjects. Researchers are also exploring its potential applications in broader obesity-related conditions, making it a valuable candidate for future therapeutic interventions.
Mechanism of Action
The primary mechanism of setmelanotide involves its selective activation of the melanocortin-4 receptor, which is integral to the central nervous system's regulation of food intake and energy expenditure. By enhancing the signaling through this receptor, setmelanotide effectively reduces hunger and promotes weight loss, making it a novel approach in the management of obesity linked to genetic factors.
Solubility and Storage Advice
Setmelanotide is soluble in water, which facilitates its administration in clinical settings. It is essential to store this compound under refrigeration, ideally between 2-8°C, to maintain its stability and efficacy. Avoiding exposure to light and keeping it in a tightly sealed container are also recommended to prevent degradation.
Future Research Directions
- Further studies are needed to evaluate the long-term safety and efficacy of setmelanotide in diverse populations.
- Exploration of combination therapies that may enhance its effectiveness in treating obesity.
- Investigating the potential of setmelanotide in other metabolic disorders beyond obesity.
As research continues, setmelanotide holds promise as a transformative treatment option for individuals suffering from genetic obesity disorders and could pave the way for innovative strategies in weight management.
| CAS Number | 920014-72-8 |
|---|---|
| Formula | C49H68N18O9S2 |
| Mol. Weight | 1117.3 g/mol |
| IUPAC Name | (4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)... |
| Grade | HPLC ≥98% |
Synthesis & Storage
Setmelanotide is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 920014-72-8, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.