glycyl-L-histidyl-L-lysine (CAS 49557-75-7) – Wholesale & Research Grade
Gly-His-Lys is a tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence. It has a role as a metabolite, a chelator, a vulnerary and a hepatoprotective agent.
Research Context
Glycyl-L-histidyl-L-lysine, commonly referred to as Gly-His-Lys or GH Lys, is a tripeptide that has garnered significant interest in biochemical and pharmaceutical research. Due to its structural properties, it is investigated for various applications, particularly in the fields of drug delivery, biochemistry, and molecular biology.
Research Applications
This tripeptide is primarily studied for its potential roles in enhancing the solubility and stability of therapeutic compounds. Its unique amino acid composition allows it to act as a stabilizing agent in peptide formulations and can enhance the bioavailability of hydrophobic drugs. Additionally, Glycyl-L-histidyl-L-lysine has shown promise in the development of peptide-based vaccines, owing to its ability to facilitate immune response modulation.
Mechanism of Action
The mechanism of action of Gly-His-Lys is mainly attributed to its ability to form stable complexes with metal ions and other biomolecules. This property is particularly useful in metal ion chelation, which can lead to applications in detoxification and therapeutic interventions for heavy metal poisoning. Moreover, its interaction with cell membranes may promote cellular uptake of co-administered drugs, enhancing their therapeutic efficacy.
Solubility and Storage Advice
Glycyl-L-histidyl-L-lysine is generally soluble in water and can be stored in a cool, dry environment to maintain its stability. It is recommended to keep this compound in a tightly sealed container, protected from light and moisture to prevent degradation. For long-term storage, refrigeration may be beneficial.
Future Research Directions
Future studies are expected to explore the full range of biological activities of Gly-His-Lys, particularly its potential in targeted drug delivery systems and as a therapeutic agent in treating various diseases. Investigations into its synthesis methods and modifications may lead to the discovery of more potent derivatives, enhancing its utility in clinical applications.
| CAS Number | 49557-75-7 |
|---|---|
| Formula | C14H24N6O4 |
| Mol. Weight | 340.38 g/mol |
| IUPAC Name | (2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]... |
| Grade | HPLC ≥98% |
Synthesis & Storage
glycyl-L-histidyl-L-lysine is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 49557-75-7, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.