LL-37 (CAS 154947-66-7) – Wholesale & Research Grade
LL-37, a well-studied antimicrobial peptide, has garnered significant attention in recent years for its diverse research applications, particularly in the fields of immunology and infectious disease. As a member of the cathelicidin family, this peptide plays a vital role in the innate immune response, exhibiting potent antibacterial, antiviral, and antifungal properties. Researchers are increasingly exploring LL-37's potential as a therapeutic agent against antibiotic-resistant pathogens, highlighting its relevance in the fight against global health threats.
Mechanism of Action
The mechanism of action of LL-37 is multifaceted. It disrupts microbial membranes, leading to cell lysis and death, while also modulating immune responses. LL-37 enhances the recruitment of immune cells to sites of infection and promotes wound healing by stimulating cell proliferation and migration. Additionally, it has been shown to possess anti-inflammatory properties, making it a subject of interest in the treatment of chronic inflammatory conditions.
Solubility and Storage
LL-37 is soluble in aqueous solutions, with optimal solubility achieved at physiological pH levels. For long-term storage, it is advisable to keep LL-37 in a lyophilized form at -20°C or lower to maintain its stability and bioactivity. Avoid repeated freeze-thaw cycles, as they may degrade the peptide's structure and function.
Future Research Directions
- Further investigation into the structure-activity relationship of LL-37 could lead to the development of more effective analogs with enhanced antimicrobial properties.
- Exploration of LL-37's role in modulating the microbiome offers an exciting avenue for research, particularly in understanding its effects on gut health and systemic immunity.
- Clinical trials focusing on LL-37's application in treating chronic wounds and skin infections are anticipated, which may pave the way for new therapeutic strategies.
Overall, LL-37 represents a promising candidate for future research, with the potential to revolutionize approaches to infection control and immune modulation.
| CAS Number | 154947-66-7 |
|---|---|
| Formula | C205H340N60O53 |
| Mol. Weight | 4493 g/mol |
| IUPAC Name | (4S)-5-[[(2S)-6-amino-1-[[(2S,3S)-1-[[2-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[... |
| Grade | HPLC ≥98% |
Synthesis & Storage
LL-37 is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 154947-66-7, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.