Cetrorelix (CAS 120287-85-6) – Research Grade is a high-purity chemical compound.

Cetrorelix is a synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast. It has a role as a GnRH antagonist and an antineoplastic agent.

Research Context

Cetrorelix is a potent gonadotropin-releasing hormone (GnRH) antagonist primarily employed in the field of reproductive medicine. This compound plays a crucial role in the regulation of hormonal pathways, particularly in the suppression of premature ovulation during assisted reproductive technologies (ART). Its efficacy in controlling the timing of ovulation makes it invaluable for in vitro fertilization (IVF) protocols, where precise hormonal manipulation is essential for successful outcomes.

Mechanism of Action

The mechanism of action of Cetrorelix involves the competitive inhibition of GnRH receptors in the pituitary gland. By blocking the action of endogenous GnRH, Cetrorelix leads to a rapid decrease in the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This results in the suppression of ovarian stimulation, preventing premature ovulation and allowing for optimal timing of oocyte retrieval during fertility treatments. As a result, Cetrorelix is frequently utilized in protocols aiming to enhance the success rates of ART procedures.

Solubility and Storage Advice

Cetrorelix is soluble in a variety of solvents, including water and alcohol, which facilitates its use in both clinical and experimental settings. It is essential to store Cetrorelix in a cool, dry place, away from light, to maintain its stability and efficacy. Proper storage conditions will ensure that researchers and clinicians can rely on the integrity of this compound for their experiments and treatments.

Future Research Directions

Future research on Cetrorelix is likely to explore its potential applications beyond reproductive medicine. Studies are being conducted to evaluate its effects in hormone-sensitive cancers and conditions like endometriosis. Additionally, researchers are investigating the pharmacokinetics and long-term outcomes associated with Cetrorelix administration in various populations. As the understanding of GnRH antagonists expands, novel therapeutic strategies may emerge, further enhancing the utility of Cetrorelix in diverse medical fields.