Ganirelix (CAS 124904-93-4) – Research Grade is a high-purity chemical compound.

Ganirelix is a polypeptide.

Research Context

Ganirelix, a prominent GnRH antagonist, is widely utilized in reproductive medicine, particularly for ovarian stimulation during assisted reproductive technologies such as in vitro fertilization (IVF). Its ability to inhibit the premature surge of luteinizing hormone (LH) is crucial for optimizing the timing of oocyte retrieval, thereby enhancing the success rates of fertility treatments.

Mechanism of Action

This compound functions by competitively binding to GnRH receptors in the anterior pituitary gland, leading to a reduction in the secretion of gonadotropins—specifically LH and follicle-stimulating hormone (FSH). By blocking these hormones, Ganirelix effectively prevents premature ovulation, allowing for better control over the ovarian stimulation protocol. This mechanism is particularly beneficial in women undergoing IVF, as it enhances the chances of retrieving viable oocytes.

Solubility and Storage Advice

Ganirelix is soluble in water, which facilitates its administration via subcutaneous injection. It is important to store this compound in a refrigerator at temperatures between 2-8°C to maintain its efficacy. Avoid freezing the solution, as this may compromise the integrity of the peptide. The shelf life of Ganirelix is typically limited, necessitating careful inventory management within laboratory settings and clinical practices.

Future Research Directions

• Investigating the long-term effects and safety profile of Ganirelix in diverse populations, including those with varying reproductive health challenges.
• Exploring the potential applications of GnRH antagonists beyond fertility treatments, such as in managing hormone-sensitive cancers.
• Assessing combination therapies that include Ganirelix with other fertility agents to enhance IVF outcomes and improve patient experiences.

As research advances, Ganirelix remains a focal point in the ongoing exploration of reproductive endocrinology, offering promising avenues for improving assisted reproduction strategies.