ACTH (4-7), Pro-Gly-Pro- (CAS 80714-61-0) – Research Grade Peptide
ACTH (4-7), Pro-Gly-Pro- is a peptide fragment derived from adrenocorticotropic hormone (ACTH) that has garnered attention in the field of biochemical research. This compound is often employed in studies related to stress response, neuroendocrine function, and therapeutic applications for adrenal insufficiency.
Research Applications
Researchers utilize ACTH (4-7), Pro-Gly-Pro- to investigate its role in the modulation of corticosteroid secretion from the adrenal cortex. This peptide is particularly relevant in studies on the hypothalamic-pituitary-adrenal (HPA) axis, providing insights into how stress and other physiological stimuli influence hormone production. Additionally, its potential neuroprotective effects make it a candidate for exploring treatments for neurodegenerative diseases.
Mechanism of Action
The mechanism of action of ACTH (4-7), Pro-Gly-Pro- primarily involves its interaction with specific receptors in the adrenal glands, leading to the stimulation of cortisol synthesis. This peptide fragment is believed to enhance the activity of steroidogenic enzymes, thereby facilitating the biosynthesis of glucocorticoids. The implications of this action extend to understanding how stress hormones affect various bodily functions, including metabolism and immune response.
Solubility and Storage Advice
ACTH (4-7), Pro-Gly-Pro- is soluble in water and can be easily incorporated into various experimental setups. For optimal stability, it is recommended to store the peptide in a lyophilized form at -20°C. Once reconstituted, it should be kept at 4°C and used within a few weeks to prevent degradation.
Future Research Directions
Future studies on ACTH (4-7), Pro-Gly-Pro- may focus on its therapeutic potential in treating conditions linked to adrenal dysfunction, such as Addison's disease. Investigating its effects on neuropsychiatric disorders and its possible role in modulating immune responses are exciting avenues for further exploration. As research progresses, the therapeutic applications of this peptide may expand, potentially leading to novel interventions in stress-related pathologies.
This peptide is available for wholesale & bulk synthesis. Get our rate sheet.
| CAS Number | 80714-61-0 |
|---|---|
| Formula | C37H51N9O10S |
| Mol. Weight | 813.9 g/mol |
| IUPAC Name | (2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylb... |
| Grade | HPLC ≥98% |
Synthesis & Storage
ACTH is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 80714-61-0, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.