Bivalirudin (CAS 128270-60-0) – Research Grade is a high-purity chemical compound.

Bivalirudin is a synthetic peptide of 20 amino acids, comprising D-Phe, Pro, Arg, Pro, Gly, Gly, Gly, Gly, Asn, Gly, Asp, Phe, Glu, Glu, Ile, Pro, Glu, Glu, Tyr, and Leu in sequence. A congener of hirudin (a naturally occurring drug found in the saliva of the medicinal leech), it a specific and reversible inhibitor of thrombin, and is used as an anticoagulant. It has a role as an anticoagulant and an EC 3.4.21.5 (thrombin) inhibitor.

Research Context

Bivalirudin, a potent direct thrombin inhibitor, has garnered significant attention in the field of cardiovascular medicine. Primarily utilized as an anticoagulant, this synthetic peptide is commonly known for its application in patients undergoing percutaneous coronary interventions (PCI) and those with unstable angina. Its efficacy in reducing thrombotic complications has made Bivalirudin a preferred alternative to traditional anticoagulants like heparin.

Research Applications

The clinical utility of Bivalirudin extends beyond its use in coronary procedures. Researchers are exploring its potential in various therapeutic areas, including:

• Management of venous thromboembolism
• Preventive strategies for stroke in atrial fibrillation patients
• Use in surgical settings where anticoagulation is necessary

Ongoing clinical trials continue to assess the implications of Bivalirudin in these contexts, aiming to refine protocols and improve patient outcomes.

Mechanism of Action

Bivalirudin exerts its anticoagulant effect by directly binding to thrombin, an essential enzyme in the coagulation cascade. This interaction inhibits thrombin's ability to convert fibrinogen to fibrin and prevents platelet activation, thereby reducing clot formation. The specificity of Bivalirudin for thrombin contributes to its efficacy and safety profile, minimizing the risk of adverse effects commonly associated with other anticoagulants.

Solubility and Storage Advice

Bivalirudin is soluble in aqueous solutions, allowing for easy administration through intravenous routes. It is advisable to store the compound in a controlled environment, protected from light and moisture, to maintain its stability and efficacy. Proper storage conditions are crucial for preserving the integrity of Bivalirudin prior to use.

Future Research Directions

<pFuture investigations may focus on optimizing dosing strategies, evaluating the long-term outcomes of Bivalirudin therapy, and exploring its potential in combination with other antithrombotic agents. Furthermore, the development of novel formulations could enhance its delivery and effectiveness, paving the way for expanded indications and improved patient care.