Glycine (CAS 56-40-6) – Wholesale & Research Grade
Glycine is the simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain. It has a role as a nutraceutical, a hepatoprotective agent, an EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor, a NMDA receptor agonist, a micronutrient, a fundamental metabolite and a neurotransmitter. It is an alpha-amino acid, a serine family amino acid and a proteinogenic amino acid. It is a conjugate base of a glycinium. It is a conjugate acid of a glycinate. It is a tautomer of a glycine zwitterion.
Research Context
Glycine, also known as aminoacetic acid or glycine amino acid, is the simplest amino acid and plays a pivotal role in various biological processes and research applications. Its unique properties make it an essential compound in the fields of biochemistry and molecular biology.
Research Applications
Glycine is widely used in research as a building block for protein synthesis and as a neurotransmitter in the central nervous system. Its role as an inhibitory neurotransmitter is vital in neuromodulation, making it a focus in studies related to neurodegenerative diseases, psychiatric disorders, and pain management. Additionally, glycine serves as a precursor for the synthesis of important biomolecules, including glutathione, heme, and creatine.
Mechanism of Action
The mechanism of action of glycine primarily involves its function as a neurotransmitter. It binds to glycine receptors in the spinal cord and brain, facilitating the opening of chloride channels, which leads to hyperpolarization of neurons and inhibition of excitatory signals. This action is crucial for maintaining a balanced neuronal environment and influences motor control and sensory processing.
Solubility and Storage Advice
Glycine is highly soluble in water, which enhances its application in various aqueous biological assays and formulations. For optimal storage, glycine should be kept in a cool, dry place, away from light. It is advisable to store it in tightly sealed containers to prevent moisture absorption and degradation.
Future Research Directions
Future research on glycine may explore its therapeutic potential in treating conditions such as schizophrenia, epilepsy, and metabolic disorders. The development of glycine-based supplements for cognitive enhancement and recovery post-exercise is also gaining interest. Furthermore, ongoing studies are investigating the role of glycine in cellular signaling pathways and its potential implications in regenerative medicine.
| CAS Number | 56-40-6 |
|---|---|
| Formula | C2H5NO2 |
| Mol. Weight | 75.07 g/mol |
| IUPAC Name | 2-aminoacetic acid |
| Grade | HPLC ≥98% |
Synthesis & Storage
Glycine is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 56-40-6, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.