Goserelin (CAS 65807-02-5) – Wholesale & Research Grade
Goserelin is an organic molecular entity.
Research Context
Goserelin, a synthetic decapeptide and a notable member of the GnRH (gonadotropin-releasing hormone) analogs, has garnered significant attention in the field of endocrine therapy. This compound is primarily used in the treatment of hormone-sensitive conditions such as prostate cancer, breast cancer, and endometriosis. Its efficacy lies in its ability to suppress the production of sex hormones, making it a vital tool in managing diseases driven by these hormones.
Mechanism of Action
The mechanism of action of goserelin involves its binding to the GnRH receptors in the pituitary gland. Initially, it stimulates a surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. However, continuous administration leads to downregulation of these receptors, resulting in a significant reduction in sex hormone production from the gonads. This phenomenon is often referred to as "medical castration" in males and is utilized to control hormone-driven tumor growth effectively.
Solubility and Storage
Goserelin exhibits good solubility in water, making it suitable for injectable formulations. When handling and storing goserelin, it is crucial to keep it in a cool, dry place, ideally at temperatures between 2°C to 8°C. Protecting it from light is also essential to maintain its stability and efficacy, as exposure can lead to degradation of the compound.
Future Research Directions
Research on goserelin continues to evolve, with studies exploring its potential applications beyond hormone-sensitive cancers. Investigations are underway to assess its efficacy in combination therapies, particularly in conjunction with immunotherapy and targeted therapies. Moreover, the exploration of goserelin in pediatric populations and other hormone-related disorders presents a promising avenue for future studies. The ongoing development of long-acting formulations may also enhance patient compliance and treatment outcomes.
In summary, goserelin remains a critical agent in hormone modulation, with ongoing research poised to expand its therapeutic horizons.
| CAS Number | 65807-02-5 |
|---|---|
| Formula | C59H84N18O14 |
| Mol. Weight | 1269.4 g/mol |
| IUPAC Name | (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-... |
| Grade | HPLC ≥98% |
Synthesis & Storage
Goserelin is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 65807-02-5, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.