Islet Amyloid Polypeptide (CAS 122384-88-7) – Wholesale & Research Grade
Islet Amyloid Polypeptide (IAPP), also known as Amylin, plays a crucial role in glucose metabolism and is a significant peptide hormone co-secreted with insulin from pancreatic beta cells. Its research applications primarily center around diabetes, particularly Type 2 diabetes mellitus, where amyloid deposits of IAPP are implicated in beta-cell dysfunction and apoptosis. Understanding the pathological role of IAPP is essential for developing therapeutic strategies aimed at preserving beta-cell function and preventing the progression of diabetes.
Mechanism of Action
The mechanism of action of Islet Amyloid Polypeptide is multifaceted. IAPP modulates glucose homeostasis by inhibiting glucagon secretion, slowing gastric emptying, and promoting satiety. However, under pathological conditions, misfolded IAPP aggregates into amyloid fibrils, leading to cytotoxic effects on pancreatic beta cells. This aggregation process is a key area of research, as it reveals insights into the molecular underpinnings of diabetes and potential targets for drug development.
Solubility and Storage Advice
Islet Amyloid Polypeptide is soluble in water, making it suitable for various in vitro applications. To maintain its stability and bioactivity, it is recommended to store IAPP at -20°C, avoiding repeated freeze-thaw cycles. Proper storage conditions are critical for preserving the integrity of the peptide, which is essential for conducting reliable experiments.
Future Research Directions
- Investigating the role of Islet Amyloid Polypeptide in other metabolic disorders beyond diabetes.
- Exploring potential therapeutic agents that can inhibit IAPP aggregation to protect beta-cell function.
- Developing IAPP analogs for use in clinical settings to enhance glucose regulation and improve patient outcomes.
As research continues, the implications of Islet Amyloid Polypeptide in diabetes and metabolic health remain a promising frontier, with the potential to yield significant breakthroughs in treatment strategies.
| CAS Number | 122384-88-7 |
|---|---|
| Formula | C165H261N51O55S2 |
| Mol. Weight | 3903.3 g/mol |
| IUPAC Name | (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-... |
| Grade | HPLC ≥98% |
Synthesis & Storage
Islet Amyloid Polypeptide is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 122384-88-7, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.