Kisspeptin-10 (CAS 374675-21-5) – Wholesale & Research Grade
Kisspeptin-10, a key peptide in reproductive biology, has garnered significant attention in recent years for its role as a potent stimulator of gonadotropin-releasing hormone (GnRH) secretion. This peptide is instrumental in the regulation of the hypothalamic-pituitary-gonadal (HPG) axis, making it a critical focus of research in endocrinology and reproductive health.
Research Applications
Kisspeptin-10 is widely utilized in studies investigating the onset of puberty, reproductive disorders, and fertility treatments. Its ability to stimulate the release of GnRH makes it a valuable tool for understanding the mechanisms underlying reproductive functions. Researchers are also exploring its potential therapeutic applications in conditions such as hypothalamic amenorrhea, polycystic ovary syndrome (PCOS), and other fertility-related issues. Additionally, Kisspeptin-10 is being evaluated for its implications in metabolic diseases and its role in the regulation of body weight and energy homeostasis.
Mechanism of Action
The mechanism of action of Kisspeptin-10 involves binding to the GPR54 receptor, which activates signaling pathways that enhance GnRH secretion. This activation triggers the downstream release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary, leading to the stimulation of gonadal function. This cascade is crucial for normal reproductive development and function.
Solubility and Storage Advice
Kisspeptin-10 is generally soluble in water and can be stored at -20°C for long-term stability. For optimal results in experimental applications, it is recommended to prepare fresh dilutions and avoid repeated freeze-thaw cycles, which can degrade the peptide's efficacy.
Future Research Directions
Future studies are expected to delve deeper into the various roles of Kisspeptin-10 beyond reproduction, including its influence on mood, behavior, and metabolic processes. Investigating its potential as a therapeutic agent for various disorders will be a key area of focus, alongside the development of Kisspeptin analogs with enhanced potency and stability. Moreover, understanding the broader implications of Kisspeptin signaling in different biological systems may unveil new avenues for intervention in both reproductive and metabolic health.
| CAS Number | 374675-21-5 |
|---|---|
| Formula | C63H83N17O14 |
| Mol. Weight | 1302.4 g/mol |
| IUPAC Name | (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S... |
| Grade | HPLC ≥98% |
Synthesis & Storage
Kisspeptin-10 is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 374675-21-5, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.