Leuprolide (CAS 53714-56-0) – Wholesale & Research Grade
Leuprolide is an oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty. It has a role as an antineoplastic agent, a gonadotropin releasing hormone agonist and an anti-estrogen.
Research Context
Leuprolide, a potent gonadotropin-releasing hormone (GnRH) analog, has garnered significant attention in the field of medical research due to its effective application in treating hormone-sensitive conditions. Commonly used in the management of prostate cancer, endometriosis, and precocious puberty, Leuprolide suppresses the production of sex hormones, thereby offering a therapeutic approach for patients suffering from these conditions.
Mechanism of Action
The mechanism of action of Leuprolide is centered around its ability to downregulate the pituitary gland's secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) through continuous stimulation of GnRH receptors. Initially, this leads to a surge in hormone levels; however, prolonged administration results in a decrease in testosterone and estrogen levels. This suppression is particularly beneficial in treating hormone-dependent cancers and various gynecological disorders.
Solubility and Storage
Leuprolide exhibits solubility in water and organic solvents, making it suitable for various formulation applications, including injectable solutions. For optimal stability, it should be stored in a cool, dry place, away from direct light. It is crucial to adhere to specific storage conditions to maintain its efficacy and prevent degradation.
Future Research Directions
Ongoing research into Leuprolide encompasses a broad spectrum of potential applications, particularly in combination therapies aimed at enhancing treatment outcomes for hormone-sensitive tumors. Investigating the long-term effects of Leuprolide therapy on quality of life and exploring its role in managing other conditions, such as polycystic ovary syndrome (PCOS) and uterine fibroids, are promising avenues for future study. Additionally, the development of novel delivery systems to improve patient compliance and optimize therapeutic efficacy presents an exciting frontier in Leuprolide research.
- Synonyms: Leuprolide Acetate
- Synonyms: Lupron
- Synonyms: Eligard
| CAS Number | 53714-56-0 |
|---|---|
| Formula | C59H84N16O12 |
| Mol. Weight | 1209.4 g/mol |
| IUPAC Name | (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diamino... |
| Grade | HPLC ≥98% |
Synthesis & Storage
Leuprolide is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 53714-56-0, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.