Lixisenatide (CAS 320367-13-3) – Research Grade is a high-purity chemical compound.

Lixisenatide is a forty-four membered polypeptide consisting of L-His, Gly, L-Glu, Gly, L-Thr, L-Phe, L-Thr, L-Ser, L-Asp, L-Leu, L-Ser, L-Lys, L-Gln, L-Met, L-Glu, L-Glu, L-Glu, L-Ala, L-Val, L-Arg, L-Leu, L-Phe, L-Ile, L-Glu, L-Trp, L-Leu, L-Lys, L-Asn, Gly, Gly, LPro, L-Ser, L-Ser, Gly, L-Ala, L-Pro, L-Pro, L-Ser, L-Lys, L-Lys, L-Lys, L-Lys, L-Lys, and L-Lys-NH2 residues joined in sequence. Used as an adjunct to diet and exercise for the treatment of adults with type II diabetes. It has a role as a glucagon-like peptide-1 receptor agonist, a hypoglycemic agent and a neuroprotective agent. It is a polypeptide and a peptidyl amide.

Research Context

Lixisenatide, a GLP-1 receptor agonist, has emerged as a pivotal therapeutic agent in the management of type 2 diabetes mellitus. Its research applications primarily focus on enhancing glycemic control and promoting weight loss in patients with obesity-related metabolic disorders. Clinical studies have demonstrated that Lixisenatide effectively stimulates insulin secretion in response to elevated blood glucose levels while simultaneously inhibiting glucagon release. This dual-action mechanism is crucial for maintaining glucose homeostasis and minimizing the risk of hypoglycemia.

Mechanism of Action

The mechanism of action of Lixisenatide involves its binding to the GLP-1 receptor, which activates intracellular signaling pathways that enhance insulin synthesis and secretion from pancreatic beta cells. Additionally, Lixisenatide slows gastric emptying, leading to increased satiety and reduced food intake. This multifaceted approach not only aids in glycemic control but also addresses the underlying issues of appetite regulation and weight management.

Solubility and Storage Advice

Lixisenatide is soluble in water, facilitating its administration via subcutaneous injection. Careful storage is essential to maintain its stability; it should be kept in a refrigerator at temperatures between 2°C and 8°C. It is crucial to protect Lixisenatide from light and to avoid freezing, as these conditions can adversely affect its efficacy. Once opened, the solution can be stored at room temperature and should be used within a specified timeframe to ensure optimal effectiveness.

Future Research Directions

Future research on Lixisenatide is expected to expand beyond its current applications in diabetes management. Investigations into its potential benefits in cardiovascular health, neurodegenerative diseases, and other metabolic disorders are underway. Moreover, combination therapies involving Lixisenatide and other antidiabetic agents may offer synergistic effects, enhancing patient outcomes. Continued exploration of Lixisenatide's pharmacological profile may reveal additional therapeutic avenues, reinforcing its significance in modern diabetes treatment.