Nicotinamide (CAS 98-92-0) – Wholesale & Research Grade
Nicotinamide is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a metabolite, a cofactor, an antioxidant, a neuroprotective agent, an EC 3.5.1.98 (histone deacetylase) inhibitor, an anti-inflammatory agent, a Sir2 inhibitor, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a geroprotector. It is a vitamin B3, a pyridinecarboxamide and a pyridine alkaloid. It is functionally related to a nicotinic acid.
Research Context
Nicotinamide, commonly known as niacinamide or nicotinic acid amide, is a versatile compound that has garnered significant attention in various fields of research, particularly in biochemistry and dermatology. This vitamin B3 derivative plays a crucial role in cellular metabolism and is essential for the synthesis of coenzymes involved in redox reactions.
Research Applications
In recent years, nicotinamide has been extensively studied for its benefits in skin health, demonstrating efficacy in treating acne, reducing hyperpigmentation, and enhancing skin barrier function. Its anti-inflammatory properties make it a popular ingredient in cosmetic formulations aimed at improving skin texture and minimizing signs of aging. Additionally, nicotinamide has shown promise in neuroprotective studies, with potential applications in mitigating neurodegenerative diseases and cognitive decline.
Mechanism of Action
The therapeutic effects of nicotinamide are largely attributed to its ability to modulate cellular signaling pathways and gene expression. It acts as a precursor for NAD+ (nicotinamide adenine dinucleotide), which is vital for energy metabolism and DNA repair. By influencing sirtuins, a class of proteins that regulate cellular health, nicotinamide may enhance mitochondrial function and promote longevity at the cellular level.
Solubility and Storage Advice
Nicotinamide is highly soluble in water and exhibits stability under various pH conditions, making it suitable for a range of applications. It should be stored in a cool, dry place, protected from light to maintain its efficacy. For long-term storage, it is recommended to keep it in tightly sealed containers to prevent moisture absorption and degradation.
Future Research Directions
As research progresses, future studies on nicotinamide are expected to explore its potential roles in metabolic diseases, its effects on inflammation, and its impact on gut health. Investigations into its synergistic effects with other compounds in skincare and pharmacology will likely yield new applications and optimize therapeutic formulations. The ongoing exploration of nicotinamide’s diverse biological activities promises to enhance our understanding of its role in health and disease.
| CAS Number | 98-92-0 |
|---|---|
| Formula | C6H6N2O |
| Mol. Weight | 122.12 g/mol |
| IUPAC Name | pyridine-3-carboxamide |
| Grade | HPLC ≥98% |
Synthesis & Storage
Nicotinamide is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 98-92-0, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.