Triptorelin (CAS 57773-63-4) – Wholesale & Research Grade
Triptorelin is an oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone. It has a role as a gonadotropin releasing hormone agonist, an antineoplastic agent and a contraceptive drug.
Research Context
Triptorelin, a synthetic analog of gonadotropin-releasing hormone (GnRH), has garnered significant attention in research and clinical applications due to its potent ability to modulate hormone levels. This peptide is commonly used in the treatment of hormone-sensitive conditions, including prostate cancer and endometriosis. Additionally, it is being explored for its potential in managing precocious puberty.
Research Applications
In the realm of endocrinology, triptorelin is employed to suppress the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to decreased testosterone and estrogen levels. This mechanism is particularly beneficial in androgen-dependent cancers and conditions where hormone regulation is critical. Furthermore, research is expanding into its use in assisted reproductive technologies, where it may aid in controlling ovarian hyperstimulation during in vitro fertilization (IVF).
Mechanism of Action
Triptorelin works by binding to GnRH receptors in the pituitary gland, initially stimulating the release of LH and FSH, followed by a downregulation of these hormones with continued administration. This results in a profound suppression of sex steroid production, making it valuable in clinical scenarios requiring hormonal modulation.
Solubility and Storage Advice
Triptorelin exhibits solubility in water, which facilitates its use in various formulations. However, to maintain stability and efficacy, it should be stored in a cool, dry place, away from light. Ideally, it should be kept at temperatures below refrigeration levels and protected from moisture to avoid degradation.
Future Research Directions
Ongoing studies aim to explore the broader applications of triptorelin beyond its current indications. Research is increasingly focusing on its potential role in neuroendocrine disorders and its possible therapeutic effects in different types of cancers beyond prostate cancer. Additionally, investigations into novel delivery methods and formulations are underway to enhance its effectiveness and patient compliance.
As investigations continue, triptorelin remains a compound of interest for researchers seeking innovative solutions in hormone modulation therapies.
| CAS Number | 57773-63-4 |
|---|---|
| Formula | C64H82N18O13 |
| Mol. Weight | 1311.4 g/mol |
| IUPAC Name | (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-... |
| Grade | HPLC ≥98% |
Synthesis & Storage
Triptorelin is supplied as a lyophilized powder to ensure stability during transit.
For long-term storage of CAS 57773-63-4, we recommend maintaining at -20°C.
Researchers must reconstitute this peptide with bacteriostatic water or sterile solvent only when ready for use.
Quality Control: All batches undergo rigorous HPLC purity testing (≥98%) prior to dispatch from our USA fulfillment center.